Somatic Mosaicism across Human Tissues Data Portal
A platform to search, visualize, and download somatic mosaic variants in normal tissues.
Latest Official Release: October 11, 2025
Benchmarking - with all technologies
CellLines
Assays
Mutations
FilesGenerated
Production - with core + additional technologies
CELL LINES & TISSUES
Ectoderm Tissues
Brain: unrelated donors
Sun-exposed skin
Endoderm Tissues
Liver
Lung
Colon
Cell Line Mixtures
COLO829 Mixture- HapMap Mixture
- iPSC & Fibroblast
AVAILABLE ASSAYS
Bulk WGS short read
- Illumina NovaSeq
- Ultima Genomics
Bulk WGS long read
- PacBio HiFi
- ONT
Bulk RNA-seq
- Illumina NovaSeq
- MAS-Seq
Single-cell WGS
- DLP+
- MALBAC
- PTA and PTA-HAT-Seq
- Cas9-targeted seq
Single-cell RNA-Seq
- snRNA-Seq
- STORM-Seq
- Tranquil-Seq
Single-molecule/duplex WGS
- Nanoseq
- CODEC
- Duplex sequencing
- HiDEF-Seq
- CompDuplex-Seq
Epigenome profiling
- NT-Seq
- Fiber-Seq
- Hi-C
- GoTchA
- ATAC-Seq/MetaCS
Data Release Tracker
CRAM CONVERSION
As of September 15, 2025, all released BAMs have been converted to CRAMs for optimal file storage at the DAC. The data release tracker will start to announce new CRAMs as they are released.
Announcements
Attention: BAM changeJul 23, 2025
As of July 8, 2025, DAC will release BAM files without the BI and BD tags, which were originally added after base quality recalibration (BQSR).
Data RetractionMar 10, 2025
One WGS ONT PromethION 24 BAM from COLO829-BLT50, SMAFIPHR8QOG, has been retracted due to sample swap.
New FeaturesJan 25, 2025
Explore the Interactive QC Assessment page for data on the portal.
Attention Users
The V1 Benchmarking data portal will be open to SMaHT consortium members only at this time.
Data-related news
- The raw sequence files, i.e. unaligned BAM and FASTQ, and the data from the benchmarking tissue samples that were not distributed by TPC will be available upon request at this time (through Globus).
- The SMaHT Data Portal, V1 Benchmarking release, now makes benchmarking data available for download for authenticated consortium members. Users can continue to obtain the access keys for metadata submission.
