Somatic Mosaicism across Human Tissues Data Portal

A platform to search, visualize, and download somatic mosaic variants in normal tissues.

Latest Release:

Tier 0: Benchmarking - with all technologies

CellLines

Assays

Mutations

FilesGenerated

Tier 1 - with core + additional technologies

Tier 2 - with core technologies

CELL LINES & TISSUES

Ectoderm Tissues
  • Brain: unrelated donors iconBrain: unrelated donors
  • Sun-exposed skin iconSun-exposed skin
Endoderm Tissues
  • Liver iconLiver
  • Lung iconLung
  • Colon iconColon
Cell Line Mixtures
  • COLO829 Mixture iconCOLO829 Mixture
  • HapMap Mixture iconHapMap Mixture
  • iPSC & Fibroblast iconiPSC & Fibroblast
Human figure diagram

AVAILABLE ASSAYS

Bulk WGS short read
  • Illumina NovaSeq
  • Ultima Genomics
Bulk WGS long read
  • PacBio HiFi
  • ONT
Bulk RNA-seq
  • Illumina NovaSeq
  • MAS-Seq
Single-cell WGS
  • DLP+
  • MALBAC
  • PTA and PTA-HAT-Seq
  • Cas9-targeted seq
Single-cell RNA-Seq
  • snRNA-Seq
  • STORM-Seq
  • Tranquil-Seq
Single-molecule/duplex WGS
  • Nanoseq
  • CODEC
  • Duplex sequencing
  • HiDEF-Seq
  • CompDuplex-Seq
Epigenome profiling
  • NT-Seq
  • Fiber-Seq
  • Hi-C
  • GoTchA
  • ATAC-Seq/MetaCS

Select a tier below to see which tissues and assays will be used

About the Consortium

NIH SMaHT Homepage
SMaHT OC Homepage
SMaHT Overview Video